Akihiro Yamanaka

资深研究员

Ph.D.

本能行为的神经调节机制，如睡眠/觉醒、进食、饮水、性行为等。

yamank(at)cibr.ac.cn

http://yamanaka.cibr.ac.cn/index.htm

教育经历

1994 日本静冈县立大学，药学学士

1996 日本静冈县立大学，药理学硕士

2000 日本筑波大学，药理学博士

工作经历

2022至今北京脑科学与类脑研究所，资深研究员

2012-2022 日本名古屋大学环境医学研究所（RIEM），教授

2008 日本国立生理学研究所（NIPS），副教授

2006 美国耶鲁大学，客座研究员

2002 日本筑波大学基础医学院药理学系，助理教授

2000 日本筑波大学基础医学院药理学系，研究助理

研究概述

下丘脑通过合成与释放神经肽调控动物本能行为，如进食行为、睡眠/觉醒行为、性行为等。实验室借助分子生物学、组织化学、电生理学、行为药理学和光遗传学等研究手段，重点关注下丘脑肽能神经元及其对本能行为的调节机制。

荣誉、奖励、学术兼职

2018-2020 日本科学技术振兴机构CREST研究员

2009-2013 日本科学技术振兴机构PRESTO研究员

2005 筑波大学最佳教师奖

2003 APSS青年科学家奖

发表文章

1. Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takikawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, *Yamashita T: Remote control of neural function by X-ray-induced scintillation. Nat Commun, 2(1):4478 (2021).

2. *Ono D, Mukai Y, Hung CJ, Chowdhury S, Sugiyama T, *Yamanaka A: The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus. Science Advances, 6(45):eabd0384 (2020).

3. Hung CJ, Ono D, Kilduff TS, *Yamanaka A: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy. eLife, 9:e54275 (2020).

4. Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, *Yamanaka A: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories. Science, 365: 1308-1313 (2019).

5. Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A: Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. eLife, 8: e44927 (2019a).

6. Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, *Yamanaka A: GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice. eLife, 8: e44928 (2019b).

7. Miyamoto D, Hirai D, Fung CC, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, *Murayama M: Top-down cortical input during NREM sleep consolidates perceptual memory. Science, 352(6291): 1315-318 (2016).

8. Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, *Yamanaka A: Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Neuropharmacol, 85: 451-60 (2014).

9. Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, *Kilduff TS, *Yamanaka A: Conditional ablation of orexin/hypocretin neurons: A new mouse model for the study of narcolepsy and orexin system function. J Neurosci, 34(19): 6495-509 (2014).

10. Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, *Yamanaka A: Optogenetic manipulation of activity and temporally-controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation. J Neurosci, 34(20): 6896-909 (2014).

11. Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, *Yamanaka A: Acute optogenetic silencing of orexin/hypocretin neurons induces slow wave sleep in mice. J Neurosci, 31(29): 10529-39 (2011).

12. *Yamanaka A, Tabuchi S, Tsunematsu T, Fukazawa Y, Tominaga M: Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor. J Neurosci, 30: 12642-52 (2010).

13. Muraki Y, *Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T: Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. J Neurosci, 24(32): 7159-66 (2004).

14. Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M, *Sakurai T: Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron, 38(5): 701-13 (2003).